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The diagnosis of HE was based on clinical, biochemical and/or liver histological data and the grade was on the widely used West-Haven criteria introduced by Conn.12 Exclusion criteria were: Non-randomized trials and observational studies

Our review is the first to investigate the role of the brain in CIPN and it paves the way for more brain-based research, more advanced and specific theories on the role of the brain in CIPN, and clinical applications to prevent and treat CIPN to ultimately reduce the burden of chemotherapy on patients with cancer

Research by Morand et al